职称：副教授

学历：博士

Email：le.fang@hbut.edu.cn

研究方向：药物分析检测探针设计与合成；蛋白靶向降解小分子药物开发；用于手术导航的近红外荧光显影剂开发。

学习经历：

2016.09—2020.10，英国伦敦玛丽女王大学，化学，博士，导师：Prof. Michael Watkinson

2013.09—2016.07，大连理工大学，功能材料化学与化工，硕士

2009.09—2013.07，江南大学，轻化工程，本科

工作经历：

2024.01—至今，湖北工业大学，副教授

2021.01—2023.12，中国科学院杭州医学研究所，博士后，合作导师：谭蔚泓院士，方晓红教授

研究课题：

1.国家自然科学基金委员会，青年科学基金项目，22104131，靶向性与响应性小分子近红外二区荧光探针用于肿瘤成像，2022-2024，30万，在研，主持；

2.中国博士后科学基金第69批面上资助二等（2021M693401），肿瘤靶向并“点亮”的小分子近红外二区荧光探针构建及卵巢癌成像应用，2021-2022，8万，结题，主持；

3. 2021年钱塘交叉基金项目，高信噪比近红外二区荧光探针用于卵巢癌成像研究，2021-2022，5万，结题，主持；

4.国家重点研发计划“前沿生物技术”专项，2022YFC3401000，肿瘤发生发展多维组学时空网络研究与表型组解析，2022-2027，2100万，在研，参与；

5.国家重点研发计划青年科学家项目，2022YFA0913300，迷你染色体的设计构建与应用，2022-2027，400万，在研，参与；

6.国家自然科学基金委员会,面上项目, 82173346,苯甲酰芍药苷靶向抑制PTPN22调控MAPK-NIS通路逆转分化型甲状腺癌碘-131抵抗的作用机制研究，2022-2025，54.7万，在研，参与；

7.浙江省尖兵领雁研发攻关项目，2023C03058，新型近红外II区分子靶向荧光探针在子宫内膜癌术中检测转移淋巴结的开发与应用研究，2023-2025，156万，在研，参与.

研究成果：

1. L. Fang, R. Ai, W. Wang, L. Tan, C. Li, D. Wang, R. Jiang, F. Qiu, L. Qi, J. Yang, W. Zhou, T. Zhu, W. Tan, Y. Jiang, and X. Fang. Hyperbranched Polymer Dots with Strong Absorption and High Fluorescence Quantum Yield for In Vivo NIR-II Imaging. Nano Lett., 2023, 23, 8734−8742. (IF: 10.8)

2. L. Fang, M. Watkinson, Subcellular localised small molecule fluorescent probes to image mobile Zn2+. Chem. Sci., 2020, 11, 11366-11379. (IF: 8.4)

3. L. Fang, G. Trigiante, R. Crespo-Otero, C. S. Hawes, M. P. Philpott, C. R. Jones and M. Watkinson. Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+. Chem. Sci., 2019, 10, 10881-10887. (IF: 8.4)

4. L. Fang, Crespo-Otero, C. R. Jones and M. Watkinson. Protect to detect: A Golgi apparatus targeted probe to image mobile zinc through the use of a lipophilic cell-labile protecting group strategy. Sensors Actuators, B Chem., 2021, 338, 129850. (IF: 8.4)

5. L. Fang, G. Trigiante, R. Crespo-Otero, M. P. Philpott, C. R. Jones and M. Watkinson. Biotin-tagged fluorescent sensor to visualize ‘mobile’ Zn2+ in cancer cells, Chem. Commun., 2018, 54, 9619-9622. (IF: 4.9)

6. J Yang,L Fang, R Jiang, L Qi, Y Xiao, W Wang, I Ismail, X Fang. RuCu Nanosheets with Ultra-high Nanozyme Activity for Chemodynamic Therapy. Adv. Healthcare Mater., 2023, 2300490. (共同一作，IF: 10.0)

7. L. Fang, G. Trigiante, R. Crespo-Otero, M. P. Philpott, C. R. Jones and M. Watkinson. An alternative modular ‘click-SNAr-click’ approach to develop subcellular localised fluorescent probes for mobile Zn2+. Org. Biomol. Chem., 2019, 17, 10013-10019. (封面文章, IF: 3.2)

8. L. Fang, Y. Hu, W. Gong, etc. Fluorescent cross-linked supramolecular polymer constructed from a novel self-complementary AABB-type heteromultitopic monomer, Org. Biomol. Chem., 2016, 14, 4039-4045. (封面文章, IF: 3.2)

9. D. Wang, W. Wang,L. Fang, L. Qi, Y. Zhang, Y Liang, J. Liu, H. Yang, Q. Xue, L Qi, W. Zhou, and X. Fang. Mitochondrial protease targeting chimeras for mitochondrial matrix protein degradation, J. Am. Chem. Soc., 2023, 145, 23, 12861–12869. (IF: 15.0)

10. W. Zhou, W. Wang, Y. Liang, R. Jiang, F. Qiu, X. Shao, J. Ni, Y. Liu, L. Wang,L. Fang, M. Ni, C. Yu, Y. Zhao, W. Li,1 W. Huang, J. Li, M. J. Donovan, D. Wang, T. Fu, J. Feng, X. Wang, W. Tan, and X. Fang. The RNA binding protein LRPPRC promotes resistance to CDK4/6 inhibition in lung cancer. Nat. Comm., 2023, 14, 4212. (IF: 16.6)

11. L. Tan, A. J. Misquitta, A. Sapelkin,L. Fang, R. M. Wilson, D. S. Keeble, B. Zhang, T. Zhu, F. Riehle, S. Han, K. Yu and M. Dove. X-ray total scattering study of magic-size clusters and quantum dots of cadmium sulphide. Nanoscale, 2019, 11, 21900-21908. (IF: 6.7)

12. A. Wajahat, X. Li,L. Fang, etc. Construction of new cross-linked supramolecular polymer with FRET phenomenon based on oligo(p-phenylenevinylene)-linked pillar[5]arene dimer. Supramol. Chem., 2018, 30, 72-79. (IF: 3.3)

13. X. Qian, W. Gong, X. Li,L. Fang, etc. Fluorescent cross-linked supramolecular polymer constructed by orthogonal self-Assembly of metal–ligand coordination and host–guest interaction. Chem. Eur. J., 2016, 22, 6881-6890. (IF: 4.3)

14. W. Gong, D. Na,L. Fang, etc. Preassembly driven ratiometric sensing dihydrogen phosphate anions in water, Org. Biomol. Chem., 2015, 13, 1979-1982. (IF: 3.2)