职 称：讲师

学 历：博士

E-mail:xxlynne@Gmail.com

研究方向：小分子药物的肿瘤靶向治疗，药理研究；药物递送介质开发；生物传感

工作经历：

1999/09-2003/07 兰州大学本科，大化学学士

2003/09-2004/12 英国诺丁汉Trent大学研究生，应用生物学硕士

2006/03-2009/11英国伍尔玆汉普顿大学RIHS研究生，生物医学博士学位

2009/03- 2009/12 英国卡迪夫大学医学院生物医学研究中心

2010/01-2016/01 英国诺丁汉大学药学院生物科学研究中心

2016/06-2019/07 肽泽（武汉）生物科技有限公司

2020/07-至今，湖北工业大学

研究课题：

Targeting Nuclear factor-kappaB pathway to improve chemotherapy of breast cancer

Targeting the nuclear-kappaB(NF-кB)pathway to improve chemotherapy of glioblastoma multiforme

Small molecular blockers of the protein interaction between AnnexinA2 and S100 proteins

人源性穿膜肽的开发和应用研究

研究成果：

1）Bing Xu*, Xiaoxia Guo*, Sumi Mathew, Angel L Armesilla, James Cassidy, John L Darling, Weiguang Wang, Triptolide simultaneously induces reactive oxygen species, inhibits NF-κB activity and sensitizes 5-fluorouracil in colorectal cancer cell lines. Cancer Letters 2010; 291: 200-8 (*joint first authors)

2）Xiaoxia Guo, Shuchita Pandey, Bing Xu, Weiguang Wang, Disulfiram/copper complex inhibiting NF-κB activity and potentiating cytotoxic effect of gemcitabine on colon and breast cancer cell lines. Cancer Letters 2010; 290: 104-13

3）Xiaoxia Guo, Elisabeth Goessl, Elaina S.R. Collie-Duguid, James Cassidy, Vincent O’brien. Cell Cycle Perturbation and Acquired 5-Fluoracil Chemoresistance. Anticancer Research 2008; 28: 9-14

4）Xiaoxia Guo, Jeff Evans, Angel Armesilla, John Darling, Andreas Schatzlein, James Cassidy, Weiguang Wang. In vitro evaluation of cancer specific NF-κB-CEA enhancer-promoter system for gene-directed enzyme prodrug therapy in colon cancer cell lines. British Journal of Cancer 2007; 97: 745-54

5）Helene K Myrvang, Xiaoxia Guo, Chan Li and Lodewijk V Dekker. Protein interactions between surface Annexin A2 and S100A10 mediate adhesion of breast cancer cells to .17microvascular endothelial cells. FEBS 2013; 587(19),3210-3215